Beloved Anthea Duarte and Red Mcrafe work as exorcists of ghosts. The heroes arrive in the city of New Eden to save the inhabitants from endless nightmares. But in a battle with a powerful spirit, Anthea dies and becomes a ghost herself. The couple embarks on a journey across the continent to find out the secret of the curse of New Eden and decide the fate of Anthea.
The gloomy tone of the Banishers: Ghosts of New Eden resembles the third "Witcher". The stories of the settlers show the underside of the human soul: residents of New Eden and other cities are often themselves guilty of the appearance of new ghosts.